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Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX

TitleFurther studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX
Publication TypeJournal Article
Year of Publication2019
AuthorsMatar H., Price S.C, Chilcott R.P
JournalToxicol In Vitro
Volume54
Pagination263-268
Date PublishedFeb
ISBN Number0887-2333 (Linking)
Accession Number30347232
Keywords*Chemical Warfare Agents, *Skin, Animals, chemical warfare agent, DECONTAMINATION, Decontamination/*methods, Female, methyl salicylate, Mustard Gas, Organothiophosphorus Compounds, PERCUTANEOUS ABSORPTION, SKIN, Skin Absorption, Soman, sulphur mustard, Swine, VX
Abstract

BACKGROUND/AIMS: Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a "therapeutic" window in which to mitigate skin absorption. METHODS: Five potential candidates (itaconic acid, N,N'-methylenebisacrylamide, 2-trifluoromethylacrylic acid, fuller's earth and Fast-Act(R)) previously found effective against a simulant (methyl salicylate) were evaluated against a 10muL droplet of (14)C-sulphur mustard (HD), soman (GD) or VX applied to the surface of porcine skin mounted on static skin diffusion cells. RESULTS: All the decontaminants applied to the skin 5min post exposure achieved a marked reduction in the amount of (14)C contaminant remaining within the skin at 24h. Itaconic acid significantly (p<.05) reduced the amount of (14)C-HD, GD and VX remaining in the skin at 24h. Additionally, 2-trifluoromethylacrylic acid significantly reduced the amount of (14)C-HD, whilst fuller's earth significantly reduced the amounts of (14)C-HD and VX recovered within the skin at 24h. CONCLUSION: All of the products evaluated in this study performed well in reducing the dermal absorption of all the chemical warfare agents tested.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/30347232
DOI10.1016/j.tiv.2018.10.008
Short TitleFurther studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX

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