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A double-blind, randomized, placebo-controlled clinical trial on the effect of carvacrol on serum cytokine levels and pulmonary function tests in sulfur mustard induced lung injury

TitleA double-blind, randomized, placebo-controlled clinical trial on the effect of carvacrol on serum cytokine levels and pulmonary function tests in sulfur mustard induced lung injury
Publication TypeJournal Article
Year of Publication2019
AuthorsKhazdair M.R, Boskabady M.H
JournalCytokine
Volume113
Pagination311-318
Date PublishedJan
ISBN Number1043-4666 (Linking)
Accession Number30075886
Keywordscarvacrol, CYTOKINES, Lung Injury, pulmonary function test, Sulfur Mustard
Abstract

OBJECTIVE: The aim of this study was to evaluate the effect of carvacrol on serum levels of interleukins (IL-2, IL-4, IL-6, IL-8, and IL-10), interferon-gamma (IFNgamma) levels and pulmonary function tests (PFT) in patients who were exposed to sulfur mustard (SM). METHODS: Twenty patients exposed to SM 27-30years ago were divided to placebo and carvacrol (1.2mg/kg/day) treated groups (n=10 for each group). Drugs were given in a double-blind manner for two months. Serum levels of cytokines and PFT values including; maximum mid-expiratory flow (MMEF) and maximum expiratory flow at 25, 50 and 75% of vital capacity (MEF25, 50 and 75) were measured at the beginning (step 0), one and two month (steps I and II, respectively) after starting the treatment. RESULTS: The serum levels of IL-2, IL-4, IL-6 and IL-8 were significantly decreased in step I and II compared to step 0 (p<0.05 to p<0.001), while the serum levels of IL-10 and IFNgamma were increased in step II compared to step 0 (p<0.01, for both cases) and IFN-gamma/IL-4 ratio was enhanced in step II compared to step 0 (p<0.001) in carvacrol treated group. MMEF, MEF75, and 50 values were significant increase in step I and II compared to step 0 (p<0.05 to p<0.001) in carvacrol treated group. CONCLUSION: Treatment with carvacrol for two months reduced inflammatory cytokine, while increased anti-inflammatory cytokines and improved PFT tests in SM induced lung injury.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/30075886
DOI10.1016/j.cyto.2018.07.031
Short TitleA double-blind, randomized, placebo-controlled clinical trial on the effect of carvacrol on serum cytokine levels and pulmonary function tests in sulfur mustard induced lung injury

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