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Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review

TitleRole of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review
Publication TypeJournal Article
Year of Publication2019
AuthorsA. Harchegani B, Khor A., Tahmasbpour E., Ghatrehsamani M., H. Kaboutaraki B, Shahriary A.
JournalCutan Ocul Toxicol
Volume38
Issue1
Pagination9-17
Date PublishedMar
ISBN Number1556-9527 (Linking)
Accession Number29969302
KeywordsAnimals, antioxidant therapy, Antioxidants/*therapeutic use, Chemical Warfare Agents/*toxicity, Humans, Mustard Gas/*toxicity, Oxidative stress, Oxidative Stress/*drug effects, Reactive Oxygen Species, Sulfur Mustard
Abstract

Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appears to be involved in SM-induced injuries. SM may trigger several molecular and cellular pathways linked to OS and inflammation that can subsequently result in cell death and apoptosis. At the acute phase of injury, SM can enhance ROS production and OS by reducing the activity of antioxidants, depletion of intercellular glutathione (GSH), decreasing the productivity of GSH-dependent antioxidants, mitochondrial deficiency, accumulation of leukocytes and pro-inflammatory cytokines. Overexpression of ROS producing enzymes and down-regulation of antioxidant enzymes are probably the major events by which SM leads to OS at the chronic phase of injury. Therefore, antioxidant therapy with potent antioxidants such as N-acetylcysteine and curcumin may be helpful to mitigate SM-induced OS damages. This review aims to discuss the proposed cellular and molecular mechanisms of acute and delayed SM toxicity, the importance of OS and mechanisms by which SM increases OS either at the acute or chronic phases of injuries along with research on antioxidant therapy as a suitable antidote.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/29969302
DOI10.1080/15569527.2018.1495230
Short TitleRole of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review

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