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A Turn-On Fluorescent Probe for Detection of Sub-ppm Levels of a Sulfur Mustard Simulant with High Selectivity

TitleA Turn-On Fluorescent Probe for Detection of Sub-ppm Levels of a Sulfur Mustard Simulant with High Selectivity
Publication TypeJournal Article
Year of Publication2018
AuthorsZhang Y., Lv Y., Wang X., Peng A., Zhang K., Jie X., Huang J., Tian Z.
JournalAnal Chem
Volume90
Issue8
Pagination5481-5488
Date PublishedApr 17
ISBN Number0003-2700 (Linking)
Accession Number29526094
Abstract

A new type of fluorescent probe capable of detecting a sulfur mustard (SM) simultant at a concentration of 1.2 muM in solution and 0.5 ppm in the gas phase has been developed. Owing to its molecular structure with a thiocarbonyl component and two piperidyl moieties integrated into the xanthene molecular skeleton, this probe underwent a highly selective nucleophilic reaction with the SM simultant and generated a thiopyronin derivative emitting intensive pink fluorescence. The distinct difference in electronic structure between the probe and thiopyronin derivative generated a marked shift of the absorption band from 445 to 567 nm, which enabled an optimal wavelength propitious for exciting the thiopyronin derivative but adverse to the probe. Such efficient separation of the excitation wavelength and tremendous increase in fluorescence quantum yield, from less than 0.002 to 0.53, upon conversion from the probe to the thiopyronin derivative, jointly led to a distinct contrast in the beaconing fluorescence signal (up to 850-fold) and therefore the unprecedented sensitivity for detecting SM species.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/29526094
DOI10.1021/acs.analchem.8b01057
Short TitleA Turn-On Fluorescent Probe for Detection of Sub-ppm Levels of a Sulfur Mustard Simulant with High Selectivity

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