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Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

TitleImprovements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant
Publication TypeJournal Article
Year of Publication2018
AuthorsZhang X.R, Zhou W.X, Zhang Y.X
JournalMil Med Res
Volume5
Issue1
Pagination30
Date PublishedSep 6
ISBN Number2054-9369 (Linking)
Accession Number30185231
Keywords*Catalytic antioxidant, *Chemical warfare agent, *Metalloporphyrins, *Pharmacodynamics, *Pharmacokinetics, *Radiation damage, Animals, Antioxidants/*pharmacology, Chemical Warfare Agents/toxicity, Humans, Lung Injury/chemically induced/*prevention & control, Metalloporphyrins/*pharmacology, Mice, Mustard Gas/toxicity, Oxidative Stress/drug effects, Radiation Injuries, Experimental/prevention & control, Radiation Pneumonitis/*drug therapy
Abstract

AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/30185231
DOI10.1186/s40779-018-0176-3
Short TitleImprovements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

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