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TGF-beta and Th17 cells related injuries in patients with sulfur mustard exposure

TitleTGF-beta and Th17 cells related injuries in patients with sulfur mustard exposure
Publication TypeJournal Article
Year of Publication2018
AuthorsPanahi Y., Ghanei M., Hassani S., Sahebkar A.
JournalJ Cell Physiol
Volume233
Issue4
Pagination3037-3047
Date PublishedApr
ISBN Number0021-9541 (Linking)
Accession Number28667758
Keywords*sulfur mustard, *TGF-beta, *Th17, Humans, Inflammation/pathology, Lung/pathology, Mustard Gas/*poisoning, T-Lymphocytes, Regulatory/immunology, Th17 Cells/*immunology, Transforming Growth Factor beta/*metabolism
Abstract

Sulfur mustard (SM) is a vesicating agent that has been employed as a chemical warfare agent. High-dose exposure to sulfur mustard may lead to the damage of rapidly proliferating cells of bone marrow and, therefore, suppression of the immune system. This may be continued as dysfunction of the immune system, and ultimately result in secondary immune disorders. Studies have suggested a role for T cells in SM-induced lung injury. Moreover, observations from animal studies indicate a delayed-type hypersensitivity (DTH) response after skin exposure to SM, providing an understanding that SM can stimulate specific T cell-mediated immune responses. On the other hand, T helper (Th) 17 cells, which are a subset of CD4+ T cells, have recently been reported to be involved in a number of inflammatory, autoimmune, and chronic fibrotic lung diseases. Furthermore, a strong association has been established between the overproduction of profibrotic cytokines like transforming growth factor (TGF)-beta and Th17 cell number. In this review, we aimed to go through the new findings about the involvement and interactions of TGF-beta and Th17 in SM-related injuries.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/28667758
DOI10.1002/jcp.26077
Short TitleTGF-beta and Th17 cells related injuries in patients with sulfur mustard exposure

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