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A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims

TitleA review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims
Publication TypeJournal Article
Year of Publication2018
AuthorsPanahi Y., Abdolghaffari A.H, Sahebkar A.
JournalJ Cell Biochem
Volume119
Issue1
Pagination197-206
Date PublishedJan
ISBN Number0730-2312 (Linking)
Accession Number28657650
Keywords*Eye, *Lung, *proteomics, *Skin, *sulfur mustard, *treatment, Animals, Chemically-Induced Disorders/diagnosis/metabolism/pathology/therapy, Humans, Male, Mustard Gas/*toxicity, PROTEOMICS
Abstract

Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apoptosis, and inflammation. Sulfur mustard penetrated body organs and induces long term eye, skin, lung, gastrointestinal, urogenital damages and can cause carcinogenic and mutagenic consequences. Currently there is no definitive treatment protocol for SM exposed patients. The goal of treatment is relieving the symptoms with fast healing rate and retrieval of damaged tissues to normal function and appearance in short period of time. Evaluation of proteomics profile in SM-exposed victims has been performed in animal model and human patients. These studies revealed that different protein were involved in the patients with SM damages to skin and lungs. Apolipoprotein A1, type I cytokeratins K14, K16 and K17, S100 calcium-binding protein A8, alpha1 haptoglobin isoforms, Amyloid A1, albumin, haptoglobin, and keratin isoforms, immunoglobulin kappa chain are defined expressed proteins in the damaged tissues.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/28657650
DOI10.1002/jcb.26247
Short TitleA review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims

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