You are here

Free Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

TitleFree Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms
Publication TypeJournal Article
Year of Publication2018
AuthorsA. Harchegani B, Tahmasbpour E., Borna H., Imamy A., Ghanei M., Shahriary A.
JournalChem Res Toxicol
Volume31
Issue4
Pagination211-222
Date PublishedApr 16
ISBN Number0893-228X (Linking)
Accession Number29569912
Keywords*Oxidative Stress, Free Radicals/chemistry/*metabolism, Humans, Lung Diseases/*chemically induced/metabolism/pathology, Mitochondria/metabolism, Mustard Gas/*adverse effects, Nitric Oxide Synthase/deficiency/metabolism, Reactive Oxygen Species/metabolism
Abstract

Sulfur mustard (SM) is a chemical alkylating compound that primary targets lung tissue. It causes a wide variety of pathological effects in respiratory system such as chronic bronchitis, bronchiolitis obliterans, necrosis of the mucosa and inflammation, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. However, molecular and cellular mechanisms for these pathologies are still unclear. Oxidative stress (OS) induced by reactive oxygen species (ROS) is likely a significant mechanism by which SM leads to cell death and tissues injury. SM can trigger various molecular and cellular pathways that are linked to ROS generation, OS, and inflammation. Hypoxia-induced oxidative stress, reduced activity of enzymatic antioxidants, depletion of intercellular glutathione (GSH), decreased productivity of GSH-dependent antioxidants, mitochondrial dysfunction, accumulation of leukocytes and proinflammatory cytokines, and increased expression of ROS producing-related enzymes and inflammatory mediators are the major events in which SM leads to massive production of ROS and OS in pulmonary system. Therefore, understanding of these molecules and signaling pathways gives us valuable information about toxicological effects of SM on injured tissues and the way for developing a suitable clinical treatment. In this review, we aim to discuss the possible mechanisms by which SM induces excessive production of ROS, OS, and antioxidants depletion in lung tissue of exposed patients.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/29569912
DOI10.1021/acs.chemrestox.7b00315
Short TitleFree Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

Theme by Danetsoft and Danang Probo Sayekti inspired by Maksimer