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Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

TitleChanges in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review
Publication TypeJournal Article
Year of Publication2017
AuthorsPohanka M., Martinkova P., Brtnicky M., Kynicky J.
JournalToxicol Mech Methods
Volume27
Issue6
Pagination408-416
Date PublishedJul
ISBN Number1537-6516 (Linking)
Accession Number28413899
KeywordsANTIOXIDANT, Antioxidants/chemistry/*therapeutic use, Bis(2-chloroethyl)sulfide, Chemical Warfare Agents/*toxicity, Humans, INFLAMMATION, Molecular Structure, Mustard Gas, Mustard Gas/*toxicity, Oxidative stress, Oxidative Stress/*drug effects, Poisoning/enzymology/*prevention & control, poly(ADP-ribose) polymerase, Sulfur Mustard
Abstract

Sulfur mustard, in a chemical name bis(2-chloroethyl) sulfide, is a chemical warfare agent. It is cytotoxic and blister forming once spread over the skin. Though exact molecular mechanism of sulfur mustard toxic action remains unknown, inflammation and oxidative stress development are considered as the most relevant pathological consequences. Applications of either low-molecular weight antioxidants or cofactors for enzymatic antioxidants are considered as suitable ways how to ameliorate the poisoning. In this article, survey of literature on countermeasures against sulfur mustard poisoning are given and evidence of oxidative stress role during sulfur mustard poisoning and availability of antioxidants for the therapy are discussed.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/28413899
DOI10.1080/15376516.2017.1320695
Short TitleChanges in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

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