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Efficacy of probiotic supplementation on quality of life and pulmonary symptoms due to sulfur mustard exposure: a randomized double-blind placebo-controlled trial

TitleEfficacy of probiotic supplementation on quality of life and pulmonary symptoms due to sulfur mustard exposure: a randomized double-blind placebo-controlled trial
Publication TypeJournal Article
Year of Publication2017
AuthorsPanahi Y., Ghanei M., Vahedi E., Mousavi S.H, Imani S., Sahebkar A.
JournalDrug Chem Toxicol
Volume40
Issue1
Pagination24-29
Date PublishedJan
ISBN Number0148-0545 (Linking)
Accession Number27079636
Keywords*inflammation, *Probiotics, *Quality of Life, *randomized controlled trial, *respiratory function, *sulfur mustard, Adult, Chemical Warfare Agents/*toxicity, Dietary Supplements, Double-Blind Method, Humans, Iran, Male, Mustard Gas/*toxicity, Probiotics/administration & dosage/adverse effects/*therapeutic use, Pulmonary Disease, Chronic Obstructive/chemically induced/*drug, Respiratory Function Tests, Surveys and Questionnaires, therapy/immunology, Treatment Outcome, Veterans, Veterans Health
Abstract

OBJECTIVE: This study investigated the efficacy and safety of supplementation with probiotics in improving chronic pulmonary symptoms due to sulfur mustard (SM) exposure. METHODS: In a randomized double-blind placebo-controlled study, 65 subjects suffering from chronic pulmonary complications of SM were assigned to one probiotic capsule (1 x 10(9) CFU containing seven strains of lactic acid-producing bacteria) every 12 h or an identical placebo for six weeks. Serum high-sensitivity C-reactive protein (CRP) concentrations, pulmonary function tests (FEV1, FEV1/FVC and MMEF 25-75%) and COPD assessment test (CAT) were assessed at baseline and at the end of trial. RESULTS: The groups were comparable in baseline characteristics. There were significant improvements in FEV1/FVC in the probiotic but not in placebo group. CAT scores were decreased in both study groups. However, between-group comparison of changes in the assessed parameters reached statistical significance only for CAT score (p < 0.001). There was no report of adverse events during the course of trial. CONCLUSIONS: Findings of the present trial favor the efficacy of probiotic supplementation in improving the pulmonary symptoms of SM-exposed subjects.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27079636
DOI10.3109/01480545.2016.1166250
Short TitleEfficacy of probiotic supplementation on quality of life and pulmonary symptoms due to sulfur mustard exposure: a randomized double-blind placebo-controlled trial

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