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Potential Utility of N-acetylcysteine for Treating Mustard Lung

TitlePotential Utility of N-acetylcysteine for Treating Mustard Lung
Publication TypeJournal Article
Year of Publication2017
AuthorsPanahi Y., Ghanei M., Hashjin M.M, Rezaee R., Sahebkar A.
JournalCrit Rev Eukaryot Gene Expr
Volume27
Issue3
Pagination247-266
ISBN Number1045-4403 (Linking)
Accession Number29199610
KeywordsAcetylcysteine/*therapeutic use, Apoptosis/drug effects, Chemical Warfare Agents/toxicity, Humans, Inflammation/chemically induced/*drug therapy/pathology, Lung Diseases/chemically induced/*drug therapy/pathology, Lung/drug effects/physiopathology, Mustard Gas/*toxicity, Oxidative Stress/drug effects
Abstract

More than a century after the introduction of sulfur mustard (SM), as a chemical warfare agent, it has affected thousands of military and civilians on several occasions. The most notable toxic effects of this easily produced chemical, are lung damage ranges from necrotic, hemorrhagic, and infectious acute-lung injury to chronic conditions (i.e., mustard lung). While there is no definite treatment for individuals exposed to sulfur mustard, corticosteroids, mucolytics, bronchodilators, antibiotics, immunosuppressive medicines, and magnesium are being used to help victims. In the pathophysiology of SM-induced lung conditions, oxidative stress and inflammation play undeniable roles; thus, N-acetyl-L-cysteine (NAC) has been used as a treatment. In this narrative review article, we discuss the mechanisms involved in SM-induced lung damage along with the properties of NAC that can help patients recover from these deleterious effects.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/29199610
DOI10.1615/CritRevEukaryotGeneExpr.2017019740
Short TitlePotential Utility of N-acetylcysteine for Treating Mustard Lung

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