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Mycosis fungoides two decades after exposure to sulphur mustard: a follow-up of 1100 victims

TitleMycosis fungoides two decades after exposure to sulphur mustard: a follow-up of 1100 victims
Publication TypeJournal Article
Year of Publication2017
AuthorsEmadi S.N, Shiri M., Shiri Z., Emadi S.E, Mortazavi H., Nikoo A., Akhavan-Moghaddam J.
JournalJ Eur Acad Dermatol Venereol
Volume31
Issue3
Pagination432-437
Date PublishedMar
ISBN Number0926-9959 (Linking)
Accession Number27699871
KeywordsAdult, Aged, Chemical Warfare Agents/*poisoning, Humans, Incidence, Iran/epidemiology, Male, Middle Aged, Mustard Gas/*poisoning, Mycosis Fungoides/chemically induced/*epidemiology/pathology, Retrospective Studies, Skin Neoplasms/chemically induced/*epidemiology/pathology, Veterans
Abstract

BACKGROUND: Sulphur mustard (SM) is an alkylating chemical warfare agent which causes acute and chronic injuries to the eyes, skin, lung and respiratory tract. OBJECTIVE: We aimed to investigate the relationship between SM poisoning and Mycosis fungoides (MF) as a late consequence. MATERIAL AND METHODS: In this retrospective study, the medical files of 1100 Iranian veterans confirmed to have exposure to SM agent during the Iraq-Iran war of the 1980s were reviewed. RESULTS: All 10 cases with MF were confirmed by clinical and histopathological examinations. The mean age of the studied subjects was 43.3 +/- 9.8 (years). In comparison to MF incidence rate in Iranian general population (0.39/100 000 person-years), we found an incidence rate of 0.799/100 000 person-years for MF among those who had short-term exposure to SM. The most common sites for SM lesions were flexural and thin skin areas. The main limitation was the retrospective design. CONCLUSION: This study indicates that the risk of MF in those exposed to SM may increase over time. Therefore, their follow-up is recommended.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27699871
DOI10.1111/jdv.13993
Short TitleMycosis fungoides two decades after exposure to sulphur mustard: a follow-up of 1100 victims

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