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Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure

TitleMustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure
Publication TypeJournal Article
Year of Publication2016
AuthorsTewari-Singh N., Agarwal R.
JournalAnn N Y Acad Sci
Volume1374
Issue1
Pagination184-92
Date PublishedJun
ISBN Number0077-8923 (Linking)
Accession Number27326543
Keywords*nitrogen mustard, *silibinin, *skin injury, *sulfur mustard, Animals, Humans, Irritants/chemistry/*toxicity, Models, Biological, Mustard Gas/chemistry/*toxicity, Silybin, Silymarin/chemistry/*pharmacology, Skin/drug effects/*pathology
Abstract

Exposure to the vesicating agents sulfur mustard (SM) and nitrogen mustard (NM) causes severe skin injury with delayed blistering. Depending upon the dose and time of their exposure, edema and erythema develop into blisters, ulceration, necrosis, desquamation, and pigmentation changes, which persist weeks and even years after exposure. Research advances have generated data that have started to explain the probable mechanism of action of vesicant-induced skin toxicity; however, despite these advances, effective and targeted therapies are still deficient. This review highlights studies on two SM analogs, 2-chloroethyl ethyl sulfide (CEES) and NM, and CEES- and NM-induced skin injury mouse models that have substantially added to the knowledge on the complex pathways involved in mustard vesicating agent-induced skin injury. Furthermore, employing these mouse models, studies under the National Institutes of Health Countermeasures Against Chemical Threats program have identified the flavanone silibinin as a novel therapeutic intervention with the potential to be developed as an effective countermeasure against skin injury following exposure to mustard vesicating agents.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27326543
DOI10.1111/nyas.13099
Short TitleMustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure

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