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Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor

TitleContributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor
Publication TypeJournal Article
Year of Publication2016
AuthorsMcNutt P.M, Tuznik K.M, Glotfelty E.J, Nelson M.R, Lyman M.E, Hamilton T.A
JournalAnn N Y Acad Sci
Volume1374
Issue1
Pagination132-43
Date PublishedJun
ISBN Number0077-8923 (Linking)
Accession Number27310673
Keywords*Cornea, *corneal epithelium, *limbal stem cell, *sulfur mustard, Animals, Cornea/drug effects/*pathology/ultrastructure, Corneal Injuries/*chemically induced, Disease Models, Animal, Environmental Exposure/*analysis, Humans, Mustard Gas/chemistry/*toxicity, Volatilization
Abstract

Corneal injuries resulting from ocular exposure to sulfur mustard (SM) vapor are the most prevalent chemical warfare injury. Ocular exposures exhibit three distinct, dose-dependent clinical trajectories: complete injury resolution, immediate transition to a chronic injury, or apparent recovery followed by the subsequent development of persistent ocular manifestations. These latter two trajectories include a constellation of corneal symptoms that are collectively known as mustard gas keratopathy (MGK). The etiology of MGK is not understood. Here, we synthesize recent findings from in vivo rabbit SM vapor studies, suggesting that tissue-specific damage during the acute injury can decrement the regenerative capacities of corneal endothelium and limbal stem cells, thereby predisposing the cornea to the chronic or delayed forms of MGK. This hypothesis not only provides a mechanism to explain the acute and MGK injuries but also identifies novel therapeutic modalities to mitigate or eliminate the acute and long-term consequences of ocular exposure to SM vapor.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27310673
DOI10.1111/nyas.13105
Short TitleContributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor

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