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Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants

TitleMacrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants
Publication TypeJournal Article
Year of Publication2016
AuthorsMalaviya R., Sunil V.R, Venosa A., Vayas K.N, Businaro R., Heck D.E, Laskin J.D, Laskin D.L
JournalAnn N Y Acad Sci
Volume1374
Issue1
Pagination168-75
Date PublishedJun
ISBN Number0077-8923 (Linking)
Accession Number27351588
Keywords*inflammatory mediators, *macrophages, *mustards, *pulmonary toxicity, Animals, Humans, Inflammation Mediators/*metabolism, Irritants/*toxicity, Lung Injury/*chemically induced/*pathology, Lung/drug effects/pathology, Macrophages/drug effects/metabolism/*pathology, Mustard Gas/*toxicity
Abstract

Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27351588
DOI10.1111/nyas.13123
Short TitleMacrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants

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