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Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

TitleMulti-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury
Publication TypeJournal Article
Year of Publication2016
AuthorsLacey C.J, Wohlman I., Guillon C., Saxena J., Fianu-Velgus C., Aponte E., Young S.C, Heck D.E, Joseph L.B, Laskin J.D, Heindel N.D
JournalAnn N Y Acad Sci
Volume1378
Issue1
Pagination174-179
Date PublishedAug
ISBN Number0077-8923 (Linking)
Accession Number27505078
Keywords*bifunctionals, *chloroethylethylsulfide, *inflammation, *phorbol ester, *Skin, *sulfur mustard, *Vesicants, Animals, Anti-Inflammatory Agents/*administration & dosage/metabolism, Chemical Warfare Agents/metabolism/*toxicity, Cholinesterase Inhibitors/administration & dosage/metabolism, Cyclooxygenase Inhibitors/administration & dosage/metabolism, Drug Delivery Systems/*methods/trends, Drug Discovery/trends, Humans, Mustard Gas/metabolism/*toxicity, Prodrugs/*administration & dosage/metabolism, Skin/*drug effects/injuries/metabolism
Abstract

The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/27505078
DOI10.1111/nyas.13177
Short TitleMulti-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

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