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Morphological Correlates of the Protection Afforded by Varma Mixture in Rat Cornea Exposed to Half Mustard (CEES): A Proposed New Treatment for Sulfur Mustard Toxicity

TitleMorphological Correlates of the Protection Afforded by Varma Mixture in Rat Cornea Exposed to Half Mustard (CEES): A Proposed New Treatment for Sulfur Mustard Toxicity
Publication TypeJournal Article
Year of Publication2000
AuthorsVarma S.D., Henein M., Ali A.H., Devamanoharan P.S., Hamilton T.A, Petrali J.P.
JournalCutan Ocul ToxicolCutan Ocul Toxicol
Volume19
Pagination153-163
Abstract

The opinions or assertions herein are the private views of the authors and are not to be construed as official or as reflecting views of the Army or the Department of Defense. In conducting this research the investigators adhered to the Guide for Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources National Research Council. Sulfur mustard gas, a bifunctional alkylating synthetic vesicating agent, has been used in warfare since World War I. It continues to be a modern chemical warfare threat agent of choice of some factions. Whole-body exposure to sulfur mustard gas, or its laboratory simulant, a monofunctional alkylating sulfur mustard, CEES, induces cutaneous, respiratory, and ocular impairments. Of these, ocular damage resulting from irritation and edema of eyelids, conjunctiva, and especially cornea causes the most immediate incapacitation. This initial ocular pathology may be followed by secondary intracorneal changes leading to severe corneal opacities. Heretofore there has been no specific prophylaxis ex-cept avoidance, and no specific therapy except palliative for mustard gas-induced ocular lesions. In the present study, we present morphological correlates of the apparent attenuation of CEES-induced ocular lesions in a rat eye model by a therapeutic mixture compound developed by Varma. Varma mixture consists of compounds known to provide bioenergetic support, reduce oxidative stress, and support tissue metabolism.

Short TitleCutaneous and ocular toxicology

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