You are here

Impairments of epithelial-nerve Interactions in sulfur mustard injuries induce long-term pathology - Indications for future treatment strategies

TitleImpairments of epithelial-nerve Interactions in sulfur mustard injuries induce long-term pathology - Indications for future treatment strategies
Publication TypeConference Proceedings
Year of Conference2006
AuthorsKadar T., Dachir S., Gutman H., Fishbeine E., Cohen L., Cohen M., Sahar R., Turetz J., Amir A.
Conference NameProceedings of the U.S. Army Medical Defense Bioscience Review
Pagination51
Conference LocationHunt Valley, MD
Abstract

Sulfur mustard (HD) is a potent vesicant known by its ability to cause incapacitation and prolonged injuries to the eyes, skin and respiratory system. All three organs share a common pathological cascade with minor distinctions originating from the unique structural characteristics of each of the tissues. Despite intensive studies, using variety of in vitro and in vivo models, pathogenesis is still elusive and currently there is no effective treatment, except for anti-inflammatory drugs. In recent years we successfully employed the cornea with its rather simple anatomic structure and its transparency as a preferable model for HD research. The transparent tissue enables in vivo viewing and ex-vivo visualization of different tissue components and the well-defined location of epithelial cell types at various stages of differentiation, enables the segregation of HD effects. Thus, the damage as well as healing processes can be monitored. We have shown in our rabbit model that despite a partial healing following the acute phase, a prolonged impairment in corneal innervation contributes to the development of a second phase of long-term pathology with symptoms typical of epithelial stem cell deficiency. It is suggested that neurotrophic changes derived from sensory deneration stimulate a chronic inflammatory response and confer a pathological microenvironment to the epithelial stem cells, thus leading to their death and to development of long-term epithelial injuries. This cascade of events may indicate new treatment strategies against HD-induced injuries, using supplement of trophic factors and stem cell transplantation.

Theme by Danetsoft and Danang Probo Sayekti inspired by Maksimer